Should you be vaccinated against Sars-CoV-2 if you have already contracted Covid-19? For now, the High Authority of Health does not comment on this subject, and indicated that it would “soon issue recommendations on the vaccination of these people” who have already contracted the disease.
This should help him in his decision: the British Medical Journal reports on two studies awaiting peer validation and publication, which suggest that a single dose of the Sars-CoV-2 coronavirus vaccine may be sufficient to protect people who have already had Covid-19 from a potential reinfection.
Carried out using vaccines from Pfizer / BioNTech or Moderna, the first study reported by the BMJ was conducted by a team from the Icahn School of Medicine at Mount Sinai in New York (United States). The study indicates that the antibody response seen after a single dose of vaccine in people who have had Covid-19 is equal to or greater (up to 10 times) to that observed after the two injections recommended in people who have never contracted the virus (known as “naive”). On the other hand, more frequent side effects have been reported by people who have already had Covid-19 (fatigue, headaches, chills, fever and muscle or joint pain), at a level close to that observed in the “naive” after the two doses in the phase III trials of these two mRNA vaccines.
In all, 109 people were included in this study, including 68 without a history of Covid-19 and 41 having already tested positive. The frequency and intensity of side effects have been observed in 231 people, including 83 who have already tested positive for Covid-19.
For the authors of the study, who indicate that it remains to ensure that the effects of a single dose are maintained over time, “the administration of a single dose to people who have had Covid-19 [leur éviterait] suffer from unnecessary pain and [permettrait] to release many urgent doses ”.
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An opinion shared by Professor Rémi Salomon
The second study was conducted by a team from the University of Maryland (United States) with 59 healthcare professionals who received a single dose of RNA vaccines from Pfizer / BioNTech or Moderna. Again, caregivers who had previously contracted Sars-CoV-2 had statistically higher levels of circulating antibodies than those who had never encountered the virus.
Asked about this subject by our colleagues from France Info, Prof. Rémi Salomon, President of the medical establishment commission of the AP-HP (Assistance publique-Hôpitaux de Paris), recommends that those who have already contracted Covid-19 get a single dose of the vaccine instead of two. Himself infected in March 2020 and having contracted “moderate form”, He indicates to have“hesitated to do this first dose of the vaccine ”.
“I spoke a little with my infectious disease colleagues who advised me to do it. In fact, it’s like a booster shot, ”he said. “Given the shortage, I think it’s important to be as economical as possible and that makes sense,” added Prof. Salomon.
It remains to be seen whether the HAS and then the government will align themselves with this opinion in the light of these two studies.
Sources: BMJ; France Info; Twitter
I did the covid in March, I received a dose, I leave the 2nd to someone else.
For those who have already made the # COVID19, a single injection of #Vaccine MRNA allows according to this study to obtain as many antibodies as with 2 injections in someone who has not been infected #SARS-CoV-2. https://t.co/b3Qns8Gjkj
– Rémi Salomon (@RemiSalomon) February 2, 2021