Diabetes is a constraining pathology, due to subcutaneous insulin injections that it requires regularly, if not daily. The scientific and medical community is therefore working to find a less invasive alternative, and with fewer undesirable effects.
In a new study published on April 6, 2021 in the journal Chemical Science, researchers at the University of New York Abu Dhabi, United Arab Emirates, report that they have developed a new technology forinsulin administration: oral.
Using layers of nanomaterials to protect and transport insulin, the researchers developed a device capable of protecting insulin even in the stomach, and without it being destroyed by stomach acids.
According to the researchers, this insulin delivery system is “biocompatible, very stable in the stomach, specific and able to provide the right amount of insulin depending on the blood sugar of the diabetic subject ”.
“Our work overcomes barriers to oral insulin delivery using nanoparticles […] loaded with insulin, which present a protection of insulin in the stomach as well as a sensitive release to glucose ”, said Farah Benyettou, co-author of the study. “This technology responds quickly to a rise in blood sugar, but would stop quickly to avoid an insulin overdose and would dramatically improve the well-being of diabetic patients.”, She added.
The development of this treatment was carried out in collaboration with an international team of researchers from Algeria, Spain, Saudi Arabia and the United Kingdom. A patent application has been filed with the US health authorities.